NEUROPROTECTIVE EFFECTS OF NBQX ON HYPOXIA-INDUCED NEURONAL DAMAGE IN RAT HIPPOCAMPUS

被引：10

作者：

MATSUOKA, Y

KITAMURA, Y

TSUKAHARA, T

TERAI, K

TOOYAMA, I

KIMURA, H

TANIGUCHI, T

机构：

[1] KYOTO PHARMACEUT UNIV,DEPT NEUROBIOL,YAMASHIMA KU,KYOTO 607,JAPAN

[2] NATL CARDIOVASC CTR,DEPT CEREBROVASC SURG,OSAKA 565,JAPAN

[3] SHIGA UNIV MED SCI,INST MOLEC NEUROBIOL,DIV NEUROANAT,OTSU,SHIGA 52001,JAPAN

来源：

NEUROREPORT | 1995年 / 6卷 / 16期

关键词：

HYPOXIA; 2,3-DIHYDROXY-6-NITRO-7-SULFAMOYL-BENZO(F)QUINOXALINE (NBQX); AMPA/KAINATE RECEPTOR; HIPPOCAMPUS; CA3; DENTATE GYRUS; NEURONAL DAMAGE; FISCHER-344; RAT;

D O I：

10.1097/00001756-199511000-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MODELS of cerebral ischaemia were used for analysis of mechanism of neuronal cell death and/or damage. Ischaemia is caused dominantly by severe hypoxia and hypoglycaemia: in the present study, we examined the influence of severe in vivo hypoxia (5% O-2/95% N-2 for 30 min at 22 degrees C). After hypoxia, neuronal damage was observed in the CA3 and dentate gyrus (DG) after 3 and 21 days of survival, but not in the CA1. 2,3-Dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX), an antagonist for AMPA/kainate receptors, showed neuroprotective effects in the CA3 and DG. These results suggest that hypoxia may induce neuronal damage in the CA3 and DG through activation of AMPA/kainate receptors.

引用

页码：2205 / 2208

页数：4

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