A STEREOSPECIFIC SYNTHESIS OF (-)-BESTATIN FROM L-MALIC ACID

被引：57
|
作者：
NORMAN, BH
MORRIS, ML
机构：
[1] Monsanto Corporate Research, Chemical Sciences, St. Louis, MO 63167
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 45期
关键词：
D O I：
10.1016/S0040-4039(00)61780-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly diastereospecific route to (-)-Bestatin from L-Malic Acid has been developed. This approach features a stereocontrolled alkylation of diethyl (S)-malate and proceeds through an oxazolidone via a Curtius Rearrangement.
引用
收藏
页码：6803 / 6806
页数：4
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