ISOLATION AND CHARACTERIZATION OF NEW PORPHYRIN METABOLITES IN HUMAN PORPHYRIA-CUTANEA-TARDA AND IN RATS TREATED WITH HEXACHLOROBENZENE BY HPTLC, HPLC AND LIQUID SECONDARY-ION MASS-SPECTROMETRY

被引：23

作者：

LUO, JL ^{[1
]}

LIM, CK ^{[1
]}

机构：

[1] UNIV LEICESTER,MRC,TOXICOL UNIT,LEICESTER LE1 9HN,LEICS,ENGLAND

来源：

BIOMEDICAL CHROMATOGRAPHY | 1995年 / 9卷 / 03期

关键词：

D O I：

10.1002/bmc.1130090302

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Porphyrin metabolisms in human porphyria cutanea tarda (PCT) and in rats treated with hexachlorobenzene (HCB) have been studied in detail by high performance thin layer chromatography (HPTLC), high performance liquid chromatography (HPLC) and Liquid secondary ion mass spectrometry (LSIMS), The analyses of porphyrin metabolites in the urine, faeces and liver biopsies of patients with PCT have shown that apart from uroporphyrin I and III and their expected decarboxylation intermediates and products, a complex mixture of many other porphyrins are present. The new porphyrins identified are: meso-hydroxyuroporphyrin III, beta-hydroxypropionic acid uroporphyrin III, hydroxyacetic acid uroporphyrin III, peroxyacetic acid uroporphyrin III, beta-hydroxypropionic acid heptacarboxylic acid porphyrin III, hydroxyacetic acid heptacarboxylic porphyrin III and peroxyacetic acid pentacarboxylic porphyrin III.

引用

页码：113 / 122

页数：10

共 13 条

[1] STRUCTURAL CHARACTERIZATION OF REACTIVE DYES USING LIQUID SECONDARY-ION MASS-SPECTROMETRY TANDEM MASS-SPECTROMETRY
RICHARDSON, SD
THRUSTON, AD
MCGUIRE, JM
WEBER, EJ
ORGANIC MASS SPECTROMETRY, 1993, 28 (05): : 619 - 625
[2] THE CHARACTERIZATION OF 2 BILIARY GLUTATHIONE CONJUGATES OF AMSACRINE USING LIQUID SECONDARY-ION MASS-SPECTROMETRY
ROBERTSON, IGC
PALMER, BD
SHAW, GJ
BIOLOGICAL MASS SPECTROMETRY, 1993, 22 (11) : 661 - 665
[3] CHARACTERIZATION OF HYDROXYEICOSATETRAENOIC ACIDS AND HYDROXYEICOSATETRAENOIC ACID PHOSPHATIDYLCHOLINES BY LIQUID SECONDARY-ION TANDEM MASS-SPECTROMETRY
ZHANG, JY
NOBES, BJ
WANG, JM
BLAIR, IA
BIOLOGICAL MASS SPECTROMETRY, 1994, 23 (07) : 399 - 405
[4] IDENTIFICATION OF RAT FECAL METABOLITES OF EBASTINE BY B/E LINKED SCANNING LIQUID SECONDARY-ION MASS-SPECTROMETRY
YOSHIDA, K
HATOYAMA, T
FUJII, T
KAGEMOTO, A
MIYAZAKI, H
NARUTO, S
BIOLOGICAL MASS SPECTROMETRY, 1994, 23 (07) : 385 - 390
[5] INTEGRATED APPLICATION OF CAPILLARY HPLC/CONTINUOUS-FLOW LIQUID SECONDARY-ION MASS-SPECTROMETRY TO DISCOVERY STAGE METABOLISM STUDIES
LI, C
CHAURET, N
DUCHARME, Y
TRIMBLE, LA
NICOLLGRIFFITH, DA
YERGEY, JA
ANALYTICAL CHEMISTRY, 1995, 67 (17) : 2931 - 2936
[6] CHARACTERIZATION OF AN OPIOID PEPTIDE-CONTAINING PROTEIN AND OF BOVINE ALPHA-LACTALBUMIN BY ELECTROSPRAY-IONIZATION AND LIQUID SECONDARY-ION MASS-SPECTROMETRY
YAN, L
TSENG, JL
FRIDLAND, GH
DESIDERIO, DM
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1994, 5 (05) : 377 - 386
[7] NORMAL-ALKYL PARAAMINOBENZOATES AS DERIVATIZING AGENTS IN THE ISOLATION, SEPARATION, AND CHARACTERIZATION OF SUBMICROGRAM QUANTITIES OF OLIGOSACCHARIDES BY LIQUID SECONDARY ION MASS-SPECTROMETRY
POULTER, L
KARRER, R
BURLINGAME, AL
ANALYTICAL BIOCHEMISTRY, 1991, 195 (01) : 1 - 13
[8] CHARACTERIZATION OF MODIFICATION SITES DURING PEPTIDE-SYNTHESIS USING LIQUID SECONDARY-ION COLLISION-INDUCED DISSOCIATION MASS-SPECTROMETRY AND A COMPUTER-PROGRAM
ROZENSKI, J
SAMSON, I
JANSSEN, G
BUSSON, R
VANAERSCHOT, A
HERDEWIJN, P
ORGANIC MASS SPECTROMETRY, 1994, 29 (11): : 654 - 658
[9] DETECTION AND CHARACTERIZATION OF NATIVE BETA-ENDORPHIN(1-31) IN BOVINE PITUITARY USING ELECTROSPRAY-IONIZATION, LIQUID SECONDARY-ION AND TANDEM MASS-SPECTROMETRY
YAN, L
TSENG, JL
DESIDERIO, DM
JOURNAL OF MASS SPECTROMETRY, 1995, 30 (04): : 531 - 540
[10] ISOLATION AND CHARACTERIZATION OF BETA-HYDROXYPROPIONIC ACID UROPORPHYRIN AND HYDROXYACETIC ACID UROPORPHYRIN-I IN THE URINE OF A PATIENT WITH CONGENITAL ERYTHROPOIETIC PORPHYRIA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND LIQUID SECONDARY ION MASS-SPECTROMETRY
GUO, R
CHAI, W
RIDEOUT, JM
LAWSON, AM
LIM, CK
BIOMEDICAL CHROMATOGRAPHY, 1990, 4 (04) : 141 - 143

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