TOMUDEX (ZD1694), A NOVEL AND SPECIFIC THYMIDYLATE SYNTHASE INHIBITOR HAS PROMISING ACTIVITY IN ADVANCED COLORECTAL-CANCER

被引：0

作者：

VANCUTSEM, E

CUNNINGHAM, D

ZALCBERG, J

FRANCOIS, E

SCHORNAGEL, JH

ADENIS, A

GREEN, M

STARKHAMMER, H

AZAB, M

机构：

[1] TOMUDEX COLORECTAL CANC STUDY GRP,MACCLESFIELD,ENGLAND

[2] ZENECA PHARMACEUT,MACCLESFIELD,ENGLAND

来源：

GASTROENTEROLOGY | 1995年 / 108卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：A548 / A548

页数：1

共 40 条

[1] ZD1694 (TOMUDEX) - A NEW THYMIDYLATE SYNTHASE INHIBITOR WITH ACTIVITY IN COLORECTAL-CANCER
JACKMAN, AL
FARRUGIA, DC
GIBSON, W
KIMBELL, R
HARRAP, KR
STEPHENS, TC
AZAB, M
BOYLE, FT
EUROPEAN JOURNAL OF CANCER, 1995, 31A (7-8) : 1277 - 1282
[2] A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor
Smith, I
Jones, A
Spielmann, M
Namer, M
Green, MD
Bonneterre, J
Wander, HE
Hatschek, T
Wilking, N
Zalcberg, J
Spiers, J
Seymour, L
BRITISH JOURNAL OF CANCER, 1996, 74 (03) : 479 - 481
[3] ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
Zalcberg, JR
Cunningham, D
VanCutsem, E
Francois, E
Schornagel, J
Adenis, A
Green, M
Iveson, A
Azab, M
Seymour, I
JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (03) : 716 - 721
[4] 'Tomudex' (ZD1694): A novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours
Cunningham, D
Zalcberg, J
Smith, I
Gore, M
Pazdur, R
Burris, H
Meropol, NJ
Kennealey, G
Seymour, L
ANNALS OF ONCOLOGY, 1996, 7 (02) : 179 - 182
[5] 'Tomudex' (ZD 1694), a new direct and specific thymidylate synthase inhibitor, has resource saving implications in the management of colorectal cancer
Kerr, D
QUALITY OF LIFE RESEARCH, 1995, 4 (06) : 576 - 576
[6] Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models
GW Aherne
E Ward
N Lawrence
D Dobinson
SJ Clarke
H Musgrove
F Sutcliffe
T Stephens
AL Jackman
British Journal of Cancer, 1998, 77 : 221 - 226
[7] Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models
Aherne, GW
Ward, E
Lawrence, N
Dobinson, D
Clarke, SJ
Musgrove, H
Sutcliffe, F
Stephens, T
Jackman, AL
BRITISH JOURNAL OF CANCER, 1998, 77 (02) : 221 - 226
[8] Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro
Patterson, AV
Talbot, DC
Stratford, IJ
Harris, AL
CANCER RESEARCH, 1998, 58 (13) : 2737 - 2740
[9] 'Tomudex' (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia
Cunningham, D
Zalcberg, JR
Rath, U
Olver, I
VanCutsem, E
Svensson, C
Seitz, JF
Harper, P
Kerr, D
PerezManga, G
Azab, M
Seymour, L
Lowery, K
Ackland, SP
Basser, RL
Clarke, SJ
Goldstein, D
Green, MD
Grygiel, JJ
McKendrick, JJ
Millward, MJ
Olver, IN
Tattersall, MHN
Thomson, DB
Jakesz, R
Buset, M
Tueni, EA
VanCutsem, EJD
Bauer, J
Beska, F
Adenis, A
Brunet, R
Francois, E
Paillot, B
Rougier, P
Fink, UFW
Knuth, KRA
Koenig, HJ
Bohme, MWJ
Wander, HE
Amadori, D
Frassineti, L
Cocconi, G
Passalacqua, R
Frigerio, F
Barni, S
Luporini, G
Labianca, R
Marini, G
Zaniboni, A
EUROPEAN JOURNAL OF CANCER, 1995, 31A (12) : 1945 - 1954
[10] FLUOROURACIL - ACTIVE IN ZD1694 (TOMUDEX)-RESISTANT CELL-LINES WITH MARKEDLY ELEVATED THYMIDYLATE SYNTHASE LEVELS
JOHNSTON, PG
BEHAN, KA
ALLEGRA, CJ
DRAKE, JC
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (20) : 1558 - 1559

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