THE ADVANTAGES OF EVAPORATIVE LIGHT-SCATTERING DETECTION IN PHARMACEUTICAL ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND SUPERCRITICAL FLUID CHROMATOGRAPHY

被引：0
|
作者：
LAFOSSE, M
ELFAKIR, C
MORINALLORY, L
DREUX, M
机构：
来源：
HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY | 1992年 / 15卷 / 05期
关键词：
LIQUID CHROMATOGRAPHY; SUPERCRITICAL FLUID CHROMATOGRAPHY; LIGHT SCATTERING DETECTION; PHARMACEUTICAL ANALYSIS;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The evaporative light scattering detector (ELSD) has been used in pharmaceutical analysis by liquid and supercritical fluid chromatography. An ELSD equipped with interchangeable interfaces enables the use of various eluents (UV- or non-UV-absorbing) in isocratic or gradient mode. Analyses were performed on several non-UV-absorbing excipients and active substances.The narrow spread of the response factors of the various compounds investigated has indicated that the detector is suitable for direct raw quantitation of unknown samples in stability studies.
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页码：312 / 318
页数：7
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