DISTRIBUTION, METABOLISM, AND EXCRETION OF MUSK XYLENE IN RATS

被引：49
|
作者：
MINEGISHI, K [1 ]
NAMBARU, S [1 ]
FUKUOKA, M [1 ]
TANAKA, A [1 ]
NISHIMAKIMOGAMI, T [1 ]
机构：
[1] NATL INST HYG SCI,DIV BIOL CHEM & BIOCHEM,TOKYO 158,JAPAN
来源：
ARCHIVES OF TOXICOLOGY | 1991年 / 65卷 / 04期
关键词：
ARTIFICIAL FRAGRANCE; MUSK XYLENE; METABOLISM (RAT); DISTRIBUTION; METABOLITES;
D O I：
10.1007/BF01968961
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Distribution, metabolism and excretion of musk xylene (MX) were investigated in male Wistar rats. Urinary and fecal excretion accounted for 10 and 75% of the dose (70 mg/kg), respectively, on day 7 after orally administration of H-3-MX to rats. Total residue of radioactivity in tissues on day 7 was less than 2.0% of the administered dose. The highest concentration was found in adipose tissue and the second was in liver. Some metabolites of MX were identified using GC-MS and NMR after purification by column or thin layer chromatography of feces, bile and urine extracts. MX, 2-NH2-MX, 2-Ac-MX, 2-NH2-3-CH2OH-MX, and 2-NH2-5-tert-BuOH-MX were found in feces, bile and urine. 4-NH2-MX and metabolite X were found in feces and urine. 4-NH2-3-CH2OH-MX was found in urine. HO-MX was found in bile. The major route of excretion for MX was the feces via bile. The reduction of the 2-nitro group of MX to the amino group was a key step in metabolism. Further metabolism of 2-NH2-MX may proceed by decreased steric hindrance of functional group.
引用
收藏
页码：273 / 282
页数：10
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