FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area

被引：20
|
作者：
von Maessenhausen, Anne [1 ]
Franzen, Alina [1 ]
Heasley, Lynn [2 ]
Perner, Sven [1 ]
机构：
[1] Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany
[2] Univ Colorado, Dept Craniofacial Biol, Aurora, CO USA
来源：
ANNALS OF TRANSLATIONAL MEDICINE | 2013年 / 1卷 / 03期
关键词：
FGFR1; lung cancer; head and neck cancer; therapeutic target; biomarker;
D O I：
10.3978/j.issn.2305-5839.2013.06.08
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.
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页数：3
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