PRIMARY STRUCTURE OF A CARDIOACTIVE NEUROPEPTIDE FROM THE TOBACCO HAWKMOTH, MANDUCA-SEXTA

被引：89
作者：
CHEUNG, CC
LOI, PK
SYLWESTER, AW
LEE, TD
TUBLITZ, NJ
机构：
[1] UNIV OREGON,INST NEUROSCI,EUGENE,OR 97403
[2] CITY HOPE NATL MED CTR,BECKMAN RES INT,DIV IMMUNOL,DUARTE,CA 91010
来源：
FEBS LETTERS | 1992年 / 313卷 / 02期
关键词：
CARDIOREGULATION; INSECT NEUROPEPTIDE; INVERTEBRATE NEUROPEPTIDE;
D O I：
10.1016/0014-5793(92)81436-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The amino acid sequence of the first of a family of insect cardioregulatory peptides from the tobacco hawkmoth, Manduca sexta, has been determined using a combination of Edman degradation microsequencing and mass spectroscopy. This peptide contains 9 amino acid residues and an observed mass for the monoisotopic protonated molecule of 956.4 Da. There are two cysteines at positions 3 and 9 forming a disulfide bridge and the carboxyl-terminus is amidated. The structure of this peptide, Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-NH2, is identical to a peptide recently isolated from crabs called crustacean cardioactive peptide (CCAP) and we propose that this peptide be named Manduca CCAP.
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页码：165 / 168
页数：4
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