DIFFERENTIAL INTRACELLULAR COMPARTMENTALIZATION OF PHOSPHOTYROSINE PHOSPHATASES IN A GLIAL-CELL LINE - TC-PTP VERSUS PTP-1B

被引：17
|
作者：
FAURE, R
POSNER, BI
机构：
[1] MCGILL UNIV, DEPT MED, MONTREAL H3A 2B2, QUEBEC, CANADA
[2] ROYAL VICTORIA HOSP, MONTREAL H3A 2B2, PQ, CANADA
来源：
GLIA | 1993年 / 9卷 / 04期
关键词：
PROTEIN TYROSINE PHOSPHATASES; LOCALIZATION; IMMUNOFLUORESCENCE; C6; GLIOMA;
D O I：
10.1002/glia.440090409
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intracellular levels of protein-phosphotyrosine are regulated by the protein-tyrosine phosphatase (PTP) family. Cellular compartmentalization may play an important role in modulating the function of these enzymes. The recent demonstration that PTP-1B is localized to the endoplasmic reticulum (Frangioni et al: Cell 68:545, 1992) is consistent with this proposition. In this study we have examined the intracellular distribution of TC-PTP in a glial cell line (C6). Using indirect immunofluorescence we have shown that this enzyme is distributed differently from PTP-1B and is mainly concentrated in the perinuclear region of these cells. (C) 1993 Wiley-Liss, Inc.
引用
收藏
页码：311 / 314
页数：4
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