INVITRO SELECTION OF RNA MOLECULES THAT BIND SPECIFIC LIGANDS

被引：7927

作者：

ELLINGTON, AD ^{[1
]}

SZOSTAK, JW ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL,BOSTON,MA 02114

来源：

NATURE | 1990年 / 346卷 / 6287期

关键词：

D O I：

10.1038/346818a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 1010 random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands. © 1990 Nature Publishing Group.

引用

页码：818 / 822

页数：5

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