Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages

被引：0
|
作者：
M. I. Dushkin
O. M. Khoshchenko
E. N. Kudinova
Ya. Sh. Schwartz
机构：
[1] Siberian Division of Russian Academy of Medical Sciences,Institute of Therapy
来源：
Bulletin of Experimental Biology and Medicine | 2006年 / 141卷
关键词：
macrophages; hydroxysterols; atorvastatin; tumor necrosis factor-α; interleukin-10;
D O I：
暂无
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摘要：
Preincubation of macrophages with atorvastatin, cholesterol, 25-, 27-hydroxycholesterol, and 7-ketocholesterol reduced the level of TNF-α to 10, 61, 13, 64.5, and 82%, respectively. Addition of mevalonate to the preincubation medium canceled the effects atorvastatin, cholesterol, and 7-ketocholesterol, but not the effects of 25-and 27-hydroxycholesterols. Atorvastatin increased the level of IL-10 by 41%, while 7-ketocholesterol and 25-hydroxycholesterol inhibited its secretion by 48 and 55%.
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页码：233 / 235
页数：2
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