Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy

被引：0
|
作者：
Qi Zhang
Guihua Chen
Xinyuan Liu
Qijun Qian
机构：
[1] Transplantation Research Institute of Sun Yat-sen University,
[2] The Third Affiliated Hospital of Sun Yat-Sen University,undefined
[3] Institute of Biochemistry and Cell Biology,undefined
[4] Chinese Academy of Sciences,undefined
[5] Laboratory of Viral and Gene Therapy,undefined
[6] Eastern Hepatobiliary Surgery Hospital,undefined
[7] Second Military Medical University,undefined
来源：
Cell Research | 2007年 / 17卷
关键词：
monoclonal antibody; cancer; gene therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the development of monoclonal antibodies for cancer treatment and summarizes the most significant clinical data for the best-established reagents to date. It also discusses strategies to improve the anti-tumor efficacy of antibody therapy, including antibody gene therapy and exploitation of bone marrow derived primary mesenchymal stem cells as the antibody gene transporter.
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页码：89 / 99
页数：10
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