A convenient synthesis of some new fused pyridine and pyrimidine derivatives of antimicrobial profiles

被引：0
|
作者：
Nagy M. Khalifa
Adel A.-H. Abdel-Rahman
Sherein I. Abd-Elmoez
Omar A. Fathalla
Amina A. Abd El-Gwaad
机构：
[1] King Saud University,Pharmaceutical Chemistry Department, College of Pharmacy
[2] National Research Centre,Department of Therapeutical Chemistry
[3] El-Menoufia University,Chemistry Department, Faculty of Science
[4] National Research Centre,Microbiology and Immunology Department
来源：
Research on Chemical Intermediates | 2015年 / 41卷
关键词：
Triazolo[1,5-; ]pyridine; Thioxopyrimidine derivatives; Antimicrobial activities;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Some novel triazolo[1,5-a]pyridine (4–6), thiazolo[3,2-a]pyridine (7), thiazolo[3,2-a]pyrimidines (9, 11), oxoimidazo[1,2-a]pyrimidine (10), and pyrimido[2,1-b]quinazoline (12) have been synthesized. The structures of target compounds were confirmed by elemental analyses and spectral data. The antimicrobial activity of some of the target synthesized compounds were tested against various microorganisms such as Salmonella typhimurium, Pseudomonas aeruginos and Staphylococcus aureus (bacteria), Aspergillus flavus (fungus), and Candida albicans (yeast fungus) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against these microorganisms.
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页码：2295 / 2305
页数：10
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