Effect of Gender and Age on the Pharmacokinetics of Repinotan

被引：0
|
作者：
Roland Heinig
Pavur Sundaresan
Anita Shah
Michael Boettcher
机构：
[1] Bayer HealthCare AG,Institute of Clinical Pharmacology
[2] Bayer Pharmaceuticals Corporation,Department of Clinical Pharmacology
[3] Bayer Pharmaceuticals Corporation,Preclinical Drug Development
来源：
Clinical Drug Investigation | 2005年 / 25卷
关键词：
Dextromethorphan; Extensive Metaboliser; Debrisoquine; Metabolic Ratio; Sparteine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: Repinotan hydrochloride (repinotan) is a selective, high-affinity, full serotonin receptor agonist at the 5-HT1a subtype that is undergoing clinical development in acute stroke. To investigate whether gender is an important covariable for repinotan pharmacokinetics, two studies were performed in subjects of different age and gender who had been phenotyped as extensive metabolisers for cytochrome P450 (CYP)2D6 using dextromethorphan as model substrate.
引用
收藏
页码：125 / 134
页数：9
相关论文
共 50 条
  • [41] Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects
    Rohatagi, S
    Gillen, M
    Aubeneau, M
    Jan, C
    Pandit, B
    Jensen, BK
    Rhodes, G
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2001, 39 (03) : 126 - 134
  • [42] The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers
    He, Yan-Ling
    Sabo, Ron
    Campestrini, Joelle
    Wang, Yibin
    Riviere, Gilles-Jacques
    Nielsen, Jace C.
    Rosenberg, Mitchell
    Ligueros-Saylan, Monica
    Howard, Dan
    Dole, William P.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 65 (03) : 338 - 346
  • [43] Lack of effect of age and gender on MK-0767 pharmacokinetics in healthy subjects.
    Rippley, RK
    Thach, C
    Hreniuk, D
    Miller, JL
    Yan, K
    Song, H
    Lasseter, KC
    Gottesdiener, KM
    Wagner, JA
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2004, 75 (02) : P58 - P58
  • [44] No effect of age or gender on the pharmacokinetics of rosuvastatin: A new HMG-CoA reductase inhibitor
    Martin, PD
    Dane, AL
    Nwose, OM
    Schneck, DW
    Warwick, MJ
    JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 42 (10): : 1116 - 1121
  • [45] Effect of age and gender on azimilide pharmacokinetics after a single oral dose of azimilide dihydrochloride
    Corey, A
    Agnew, J
    Bao, J
    Bryson, P
    Comer, P
    Griffith, S
    Li, JF
    JOURNAL OF CLINICAL PHARMACOLOGY, 1997, 37 (10): : 946 - 953
  • [46] THE EFFECT OF AGE ON THE PHARMACOKINETICS OF PENTISOMIDE
    HOLT, DW
    WALKER, S
    JOHNSTON, A
    JONES, RW
    HOWSE, NL
    DARRAGH, A
    CAFFREY, E
    BIOPHARMACEUTICS & DRUG DISPOSITION, 1991, 12 (08) : 627 - 631
  • [47] EFFECT OF AGE ON DIGOXIN PHARMACOKINETICS
    KORKUSHKO, OV
    ORLOV, PA
    BEZVERKHAYA, IS
    BELYI, AA
    FARMAKOLOGIYA I TOKSIKOLOGIYA, 1984, 47 (03): : 101 - 104
  • [48] THE EFFECT OF AGE ON THE PHARMACOKINETICS OF TRIMAZOSIN
    MEREDITH, PA
    SCOTT, PJW
    SUMNER, DJ
    CAMPBELL, L
    HUGHES, DMA
    RUBIN, PC
    REID, JL
    SCOTTISH MEDICAL JOURNAL, 1986, 31 (02) : 140 - 140
  • [49] THE EFFECT OF AGE ON THE PHARMACOKINETICS OF TRIMAZOSIN
    MEREDITH, PA
    SCOTT, PW
    SUMNER, DJ
    CAMPBELL, L
    HUGHES, DMA
    RUBIN, PC
    REID, JL
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 20 (05) : P533 - P534
  • [50] The effect of age on the pharmacokinetics of valsartan
    Sioufi, A
    Marfil, F
    Jaouen, A
    Cardot, JM
    Godbillon, J
    Ezzet, F
    Lloyd, P
    BIOPHARMACEUTICS & DRUG DISPOSITION, 1998, 19 (04) : 237 - 244
12345