Magnetic Resonance Morphometry of Neuroplastic Changes in the Brain during Conservative Treatment of Traumatic Brachial Plexopathy

Objectives. To identify neuroplastic changes in brain structures in the treatment of traumatic axonotomy of the brachial plexus using MR morphometry data. Materials and methods. MR morphometry of the gray and white matter of the brain was studied in 62 patients with traumatic axonopathy of the brachial plexus. Results. Correlational relationships were identified between the thickness of the sensorimotor cortex and the morphometric parameters (volume, diffuseness, fractional anisotropy) of subcortical formations (the corticospinal tracts, the forceps minor (frontal) of the corpus callosum) of the brain with the severity of neurological impairments and the dynamics of neurological deficit depending on therapeutic strategy. Conclusions. The data obtained here expand current concepts of the central mechanisms of post-traumatic axon regeneration in a model of traumatic brachial plexopathy and identify the patterns of neuroplastic processes in the CNS and the neuromodulatory effect of Neuromidin and Noofen. Use of individual morphometric parameters as markers for reactive neuroplastic processes in the CNS is suggested. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.