Passing the baton in base excision repair

被引：0

作者：

Samuel H. Wilson

Thomas A. Kunkel

机构：

[1] Laboratory of Structural Biology,

[2] National Institute of Environmental Health Sciences,undefined

来源：

Nature Structural Biology | 2000年 / 7卷 / 3期

关键词：

D O I：

10.1038/73260

中图分类号：

学科分类号：

摘要：

Apurinic/apyrmidinic endonuclease 1 (APE1) plays a central role in DNA repair by cleaving the DNA backbone 5′ of AP sites that result from removal of damaged bases. New structural findings on APE1–DNA cocrystals provide insights into how this enzyme binds and cleaves its substrate and how, like one member in an efficient relay team, it coordinates potentially dangerous steps in the base excision repair pathway.

引用

页码：176 / 178

页数：2

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