Synthesis, Structure, and Antiproliferative Activity of trans-Palladium(II) Complexes with Tetrazol-2-ylacetic Acid Derivatives

被引：0
|
作者：
E. A. Popova
O. V. Mikolaichuk
A. V. Protas
A. V. Mukhametshina
G. K. Ovsepyan
G. L. Starova
R. V. Suezov
A. V. Fonin
R. E. Trifonov
机构：
[1] St. Petersburg State University,Institute of Cytology
[2] St. Petersburg State Institute of Technology,undefined
[3] Russian Academy of Sciences,undefined
来源：
Russian Journal of General Chemistry | 2018年 / 88卷
关键词：
tetrazole-containing Pd(II) complexes; tetrazol-2-ylacetic acid derivatives; interaction with DNA; antiproliferative activity;
D O I：
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中图分类号：
学科分类号：
摘要：
A series of trans-palladium(II) complexes (trans-[PdCl2L2], L = ethyl 5-R-2H-tetrazol-2-ylacetate, 5-R-2H-tetrazol-2-ylacetamides, R = Me, Ph) has been synthesized, and their structure has been proved by 1H and 13C–{1H} NMR and high-resolution mass spectra and X-ray analysis. Antiproliferative activity of the synthesized complexes has been determined, and the mechanism of their interaction with DNA has been studied by UV and CD spectroscopy.
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页码：2354 / 2358
页数：4
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