Irritable Bowel Syndrome and Gastroesophageal Reflux Disease in Primary Care: Is There a Link?

被引：0
|
作者：
Ana Ruigómez
Mari-Ann Wallander
Saga Johansson
Luis Alberto García Rodríguez
机构：
[1] Spanish Centre for Pharmacoepidemiological Research (CEIFE),Department of Public Health and Caring Science
[2] AstraZeneca R&D,Institute of Medicine, Sahlgrenska Academy
[3] Uppsala University,undefined
[4] Gothenburg University,undefined
来源：
Digestive Diseases and Sciences | 2009年 / 54卷
关键词：
Database; Epidemiology; Gastroesophageal reflux; Irritable bowel syndrome; Primary health care;
D O I：
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中图分类号：
学科分类号：
摘要：
Population-based studies have shown that gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) coexist more commonly than expected by chance. We aimed to investigate the relationship between GERD and IBS in primary care. The General Practice Research Database was used to identify patients with a first diagnosis of GERD (n = 6,421) or IBS (n = 2,932). Patients were followed up for 12 months after diagnosis to investigate the incidence of IBS among GERD patients and GERD among IBS patients. The relative risk (RR) of developing IBS was 3.5 (95% CI: 2.3–5.4) in the GERD cohort compared with the comparison cohort. The RR of developing GERD was 2.8 (95% CI: 1.7–4.9) in the IBS cohort compared with the comparison cohort. A first diagnosis of either IBS or GERD significantly increases the risk of a subsequent diagnosis of the other condition.
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页码：1079 / 1086
页数：7
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