A case of Cowden's syndrome presenting with gastric carcinomas and gastrointestinal polyposis

被引：0
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作者：
Khalid Al-Thihli
Laura Palma
Victoria Marcus
Matthew Cesari
Yael B Kushner
Alan Barkun
William D Foulkes
机构：
[1] A Barkun is a Research Scholar (Chercheur National) of the Fonds de la Recherche en Santé du Québec,K Al
[2] and WD Foulkes is an Associate Professor and Director of the Program in Cancer Genetics,Thihli is a fifth
[3] all at McGill University Health Centre,year Resident in the Department of Human Genetics, and L Palma is a Genetic Counselor in the Department of Medical Genetics, V Marcus is a Surgical Pathologist and Assistant Professor and M Cesari and YB Kushner are
[4] Montreal,undefined
[5] Quebec,undefined
[6] Canada.,undefined
来源：
Nature Reviews Gastroenterology & Hepatology | 2009年 / 6卷
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摘要：
This article considers the case of a 73-year-old white man who presented with synchronous gastric carcinomas and a 20-year history of mixed polyposis. Genetic-testing and molecular-pathology analyses confirmed a diagnosis of Cowden's syndrome. The case explores the diagnostic challenges of differentiating between hamartomatous and adenomatous polyposis syndromes in patients with mixed polyposis, and emphasizes the need to characterize the risk of gastrointestinal cancer in patients with this syndrome.
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页码：184 / 189
页数：5
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