CRISPR technologies for precise epigenome editing

被引：0
|
作者：
Muneaki Nakamura
Yuchen Gao
Antonia A. Dominguez
Lei S. Qi
机构：
[1] Stanford University,Department of Bioengineering
[2] Stanford University,Cancer Biology Program
[3] Stanford University,Department of Chemical and Systems Biology
[4] Stanford University,Stanford ChEM
[5] Mammoth Biosciences,H Institute
[6] Sana Biotechnology,undefined
来源：
Nature Cell Biology | 2021年 / 23卷
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学科分类号：
摘要：
The epigenome involves a complex set of cellular processes governing genomic activity. Dissecting this complexity necessitates the development of tools capable of specifically manipulating these processes. The repurposing of prokaryotic CRISPR systems has allowed for the development of diverse technologies for epigenome engineering. Here, we review the state of currently achievable epigenetic manipulations along with corresponding applications. With future optimization, CRISPR-based epigenomic editing stands as a set of powerful tools for understanding and controlling biological function.
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页码：11 / 22
页数：11
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