Synthesis and antioxidant properties of 3-methyl-substituted thiazolo[3,2-a]benzimidazole

被引：0

作者：

V. M. Dianov

机构：

[1] Bashkir State Medical University,

来源：

Pharmaceutical Chemistry Journal | 2007年 / 41卷

关键词：

Adrenaline; Antioxidant Property; Benzimidazole; Secondary Amine; Benzimidazole Derivative;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3-Aminomethyl-substituted thiazolo[3,2-a]benzimidazoles were synthesized by reacting 3-(chloromethyl) thiazolo[3,2-a]benzimidazole with primary and secondary amines. The resulting 3-amino-derivatives of thiazolobenzimidazole were tested in vitro for antioxidant properties in relation to the autooxidation of adrenaline to adrenochrome. All the compounds studied inhibited, to different extents, the oxidation of adrenaline to adrenochrome, thus preventing formation of the superoxide radical.

引用

页码：308 / 309

页数：1

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