Toxicological effects of multi-wall carbon nanotubes in rats

被引：0
|
作者：
Aihong Liu
Kangning Sun
Jiafeng Yang
Dongmei Zhao
机构：
[1] Engineering Ceramics Key Laboratory of Shandong Province,Key Laboratory of Liquid Structure and Heredity of Materials ministry of Education
[2] Material Science and Engineering Institute,undefined
[3] Shandong University,undefined
[4] The Second Hospital of Shandong University,undefined
来源：
Journal of Nanoparticle Research | 2008年 / 10卷
关键词：
Multi-wall carbon nanotubes; Lung toxicity; Nanomaterials; Intratracheal instillation; MWCNT; Nanomedicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study was to evaluate the lung toxicity of multi-wall carbon nanotubes (MWCNTs). The present work exposed MWCNTs into the rats in intratracheal instillation administration modes. We systematically studied the distribution of nanoparticles in vivo, target organs and time-effects of nanotoxicity, dose-effects of nanotoxicity, etc. These results indicate that under the conditions of this test, pulmonary exposures to MWCNTs in rats by intratracheal instillation produced a series of multiple lesions in a dose-dependent and time-dependent manner, evidence of a foreign tissue body reaction.
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页码：1303 / 1307
页数：4
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