Synthesis and antiplatelet activity of 2-substituted imidazolines

被引：0
|
作者：
R. M. Sultanova
N. S. Khusnutdinova
Yu. G. Borisova
G. Z. Raskildina
S. A. Meshcheryakova
A. V. Samorodov
S. S. Zlotskii
机构：
[1] Ufa State Petroleum Technological University,
[2] Bashkir State Medical University,undefined
来源：
Russian Chemical Bulletin | 2023年 / 72卷
关键词：
carboxylic acids; ethylenediamine; imidazolines; condensation; alkylation; antiplatelet activity;
D O I：
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中图分类号：
学科分类号：
摘要：
2-Substituted 4,5-dihydro-1H-imidazoles were synthesized by the condensation of aromatic carboxylic acids with ethylenediamine in the presence of KU-2/8 cation-exchange resin as a catalyst. Subsequent alkylation of the resulting compounds with 2-chloromethyl-gem-dichlorocyclopropane or 2-bromomethyl-1,3-dioxolane gave previously unknown substituted imidazolines containing carbo- and heterocyclic fragments. The synthesized 2-substituted 4,5-dihydro-1H-imidazoles were found to possess the antiplatelet activity at the level of acetylsalicylic acid.
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页码：1711 / 1716
页数：5
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