Immunohistochemical Studies Using Immunized Guinea Pig Sera with Features of Anti-Human Thyroid, Eye and Skeletal Antibody and Graves’ Sera

被引：0
|
作者：
IldikÓ MolnÁr
Zita Szombathy
Ilona KovÁcs
A. JÓZsef SzentmiklÓsi
机构：
[1] Kenézy County and Teaching Hospital,3rd Department of Internal Medicine
[2] Kenézy County and Teaching Hospital,Pathology
[3] University Debrecen,Department of Pharmacology and Pharmacotherapy
[4] Medical and Health Science Center,3rd Department of Internal Medicine
[5] Kenézy County and Teaching Hospital,undefined
来源：
Journal of Clinical Immunology | 2007年 / 27卷
关键词：
Type 2 5′ deiodinase; Graves’ ophthalmopathy; antibodies; eye and skeletal muscle; thyroid;
D O I：
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学科分类号：
摘要：
Type 2 5′ deiodinase enzyme was observed in both thyroid and eye muscle tissues, highlighting its possible role as a common antigen in thyroid-associated ophthalmopathy. Sera of 105 Graves’ patients and 40 controls, and immunized guinea pig sera against TCSS peptide, showing homology to the amino acid sequence from 132 to 152 of type 2 5′ deiodinase, were investigated to demonstrate the binding effects to human thyroid, eye and skeletal muscle tissues.
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页码：172 / 180
页数：8
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