Dimethylarginines and Serotonin in the Blood of Spontaneously Hypertensive Rats

被引：0
|
作者：
M. A. Gilinsky
T. V. Latysheva
G. M. Petrakova
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Institute of Physiology
来源：
Bulletin of Experimental Biology and Medicine | 2009年 / 148卷
关键词：
rats; hypertension; serotonin; nitric oxide; dimethylarginines;
D O I：
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学科分类号：
摘要：
The serotoninergic system and nitric oxide system were studied in spontaneously hypertensive rats SHR and Wistar rats (control). The contents of serotonin, 5-hydroxyindoleacetic acid (serotonin metabolite), L-arginine, monomethylarginine, and asymmetric and symmetric dimethylarginines were measured in blood plasma. Serotonin content in hypertensive animals was much higher than in Wistar rats. No interstrain differences were found in the concentration of 5-hydroxyindoleacetic acid. The concentration of asymmetric dimethylarginine in SHR rats was higher than in Wistar rats. However, the concentration of monomethylarginine in SHR rats was lower than in Wistar rats. Our results and published data on the serotoninergic system indicate that SHR rats serve as a convenient model of hypertension.
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页码：849 / 851
页数：2
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