ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

被引：0

作者：

Weiyi Toy

Yang Shen

Helen Won

Bradley Green

Rita A Sakr

Marie Will

Zhiqiang Li

Kinisha Gala

Sean Fanning

Tari A King

Clifford Hudis

David Chen

Tetiana Taran

Gabriel Hortobagyi

Geoffrey Greene

Michael Berger

José Baselga

Sarat Chandarlapaty

机构：

[1] Human Oncology and Pathogenesis Program,Ben May Department of Cancer Research

[2] Memorial Sloan-Kettering Cancer Center (MSKCC),Department of Surgery

[3] Toyota Technological Institute at Chicago,Solid Tumor Division, Department of Medicine

[4] University of Chicago,Department of Breast Medical Oncology

[5] Breast Service,Department of Pathology

[6] MSKCC,undefined

[7] Weill Cornell Medical College,undefined

[8] Breast Cancer Medicine Service,undefined

[9] MSKCC,undefined

[10] Novartis Pharmaceuticals Corporation,undefined

[11] MD Anderson Cancer Center,undefined

[12] MSKCC,undefined

来源：

Nature Genetics | 2013年 / 45卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Sarat Chandarlapaty and colleagues report the identification of mutations in the ESR1 gene affecting the ligand-binding domain of the encoded estrogen receptor in 20% of metastatic hormone-resistant breast cancers. They determine that the mutant receptor has a hormone-independent active state that likely promotes resistance to estrogen-depriving therapies.

引用

页码：1439 / 1445

页数：6

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