Dose Response of Adrenocorticotropin and Cortisol to the CCK-B Agonist Pentagastrin

被引:0
|
作者
James L Abelson
Israel Liberzon
机构
[1] University of Michigan,Department of Psychiatry, Department of Psychiatry
[2] Anxiety Disorders Program,undefined
[3] and Ann Arbor Veterans Administration Medical Center,undefined
来源
Neuropsychopharmacology | 1999年 / 21卷
关键词
Cholecystokinin; Adrenocorticotropin; Cortisol; Anxiety; Panic disorder;
D O I
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中图分类号
学科分类号
摘要
Cholecystokinin (CCK) is an abundant neurotransmitter in brain. Its functional significance in humans is incompletely understood, but it may modulate activity in the hypothalamic–pituitary-adrenal (HPA) axis. To explore this hypothesis, we examined the effects of varying doses (0 to 0.8 μg/kg) of the CCK-B agonist pentagastrin on adrenocorticotropin (ACTH) and cortisol release in healthy human subjects. We also examined anxiety, heart rate (HR), and blood pressure (BP) responses. Pentagastrin induced large (up to 520 % increase over baseline), significant and very rapid, dose-dependent elevations in ACTH and cortisol levels. Significant elevations in HR and BP were seen at all doses, without clear dose-response relationships. Anxious distress and symptom responses were also somewhat dose dependent; but hormonal responses were more robustly linked to pentagastrin dose than to these subjective measures. The HPA axis response to the CCK-B agonist pentagastrin may be a direct pharmacological effect. Further work is needed to determine the mechanisms and the physiological significance of CCK-mediated modulation of the human neuroendocrine stress axis.
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页码:485 / 494
页数:9
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