Sequential injection technique for the determination of chlorpromazine hydrochloride in pure form and pharmaceutical formulations

A simple, economical, and automated spectrophotometric method for the determination of chlorpromazine hydrochloride by sequential injection analysis using ammonium metavanadate as colorimetric reagent is proposed. The various chemical and physical conditions that affected the reaction have been thoroughly investigated. The calibration curve was linear within the range 10–100 μg/mL. The detection limit (S/N = 3) was 0.7 μg/mL and the limit of quantification (S/N = 10) was 2.3 μg/mL. The sampling frequency was 22 h−1. The method has been used for the determination of chlorpromazine hydrochloride in pure form and pharmaceutical formulations. The t-test has revealed that there is no evidence of significant differences between the obtained results at the 95% confidence level. The method can be applied to the quantitative determination of chlorpromazine hydrochloride. It is also applicable in the quality control of chlorpromazine hydrochloride preparations.