Optical Analysis of Zinc Oxide Quantum Dots with Bovine Serum Albumin and Bovine Hemoglobin

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作者
Rizwan Wahab
Sourabh Dwivedi
Mohd Shahnawaz Khan
Abdulrahman M. Al-Senaidy
Hyung-Shik Shin
Javed Musarrat
Abdulaziz A. Al-Khedhairy
机构
[1] King Saud University,Department of Zoology, College of Science
[2] King Saud University,Department of Biochemistry, College of Science
[3] Chonbuk National University,Energy Materials and Surface Science Laboratory, Solar Research Center, School of Chemical Engineering
[4] AMU,Department of Agricultural Microbiology, Faculty of Agricultural Sciences
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Quantum dots; Bovine serum albumin; Bovine hemoglobin; Circular dichroism;
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摘要
Quantum dots (QDs) are widely used in medical, industrial, and household applications owing to their excellent biological property. For its wide medical application, the biocompatibility of QDs is an important aspect of research. The aim of the present study was to synthesize zinc oxide quantum dots (ZnO-QDs) and to investigate the interaction with bovine serum albumin (BSA) and bovine hemoglobin (BHb) using fluorescence quenching method and circular dichroism (CD). The study suggests that the electrostatic force of attraction favors the adsorption of BSA onto ZnO-QDs. The fluorescence quenching of BSA and BHb using QD indicates the formation of QDs-BSA complexes. The CD spectra also showed the changes in secondary structure of proteins by interacting with QDs.
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页码:48 / 52
页数:4
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