Heterocyclic analogs of combretastatin A-4

被引：0
|
作者：
S. F. Vasilevsky
M. P. Davydova
G. A. Tolstikov
机构：
[1] Siberian Branch of the Russian Academy of Sciences,Institute of Chemical Kinetics and Combustion
[2] Siberian Branch of the Russian Academy of Sciences,N. N. Vorozhtsov Institute for Organic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2008年 / 44卷
关键词：
acetylenes; combretastatin A-4; heterocyclization; homogeneous catalysis; cross-coupling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel route is proposed for the synthesis of heterocyclic analogs of the naturally occurring combretastatin A-4 based on the reaction of α-acetylenic ketones with polyfunctional nucleophiles (hydroxylamine, hydrazine, guanidine). Previously unknown combretastatin A-4 analogs with azole and azine bridges were obtained.
引用
收藏
页码：1257 / 1261
页数：4
相关论文
共 50 条
  • [1] Heterocyclic analogs of combretastatin A-4
    Vasilevsky, S. F.
    Davydova, M. P.
    Tolstikov, G. A.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2008, 44 (10) : 1257 - 1261
  • [2] Combretastatin a-4 analogs as anticancer agents
    Chaudhary, Anurag
    Pandeya, S. N.
    Kumar, P.
    Sharma, Py.
    Gupta, S.
    Soni, N.
    Verma, K. K.
    Bhardwaj, G.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2007, 7 (12) : 1186 - 1205
  • [3] Synthesis of Combretastatin A-4 Analogs and their Biological Activities
    Siebert, Agnieszka
    Gensicka, Monika
    Cholewinski, Grzegorz
    Dzierzbicka, Krystyna
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2016, 16 (08) : 942 - 960
  • [4] Acetyl analogs of combretastatin A-4: Synthesis and biological studies
    Babu, Balaji
    Lee, Megan
    Lee, Lauren
    Strobel, Raymond
    Brockway, Olivia
    Nickols, Alexis
    Sjoholm, Robert
    Tzou, Samuel
    Chavda, Sameer
    Desta, Dereje
    Fraley, Gregory
    Siegfried, Adam
    Pennington, William
    Hartley, Rachel M.
    Westbrook, Cara
    Mooberry, Susan L.
    Kiakos, Konstantinos
    Hartley, John A.
    Lee, Moses
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (07) : 2359 - 2367
  • [5] Theoretical studies on the structures and properties of combretastatin A-4 and its five-membered heterocyclic structural analogs
    Pang, Jiangmei
    Huang, Xuhui
    Wei, Huining
    Xia, Xiaoyun
    Lin, Zishan
    Zhu, Yindi
    Wang, Kun
    Wang, Chaojie
    CHEMICAL PAPERS, 2025, 79 (04) : 2567 - 2584
  • [6] Design, stereoselective synthesis, and antitumoral activity of combretastatin A-4 analogs
    da Silva, Wilson P.
    Caiana, Robrigo R. A.
    Barros, Maria E. S. B.
    Freitas, Juliano C. R.
    da Silva, Paulo B. N.
    Milita, Gardenia G. C.
    Oliveira, Roberta A.
    Menezes, Paulo H.
    RESULTS IN CHEMISTRY, 2024, 7
  • [7] Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4
    Thi Thanh Binh Nguyen
    Lomberget, Thierry
    Ngoc Chau Tran
    Colomb, Evelyne
    Nachtergaele, Lore
    Thoret, Sylviane
    Dubois, Joelle
    Guillaume, Joren
    Abdayem, Rawad
    Haftek, Marek
    Barret, Roland
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (23) : 7227 - 7231
  • [8] Significance of Amino Group Substitution at Combretastatin A-4 and Phenstatin Analogs
    Patel, Vijay K.
    Rajak, Harish
    LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 13 (09) : 943 - 951
  • [9] Pyrazoline analogs of Combretastatin A-4: Synthesis, biological evaluation and tubulin inhibition
    Younglove, Brent
    Lee, Lauren
    Mackay, Hilary
    Mooberry, Susan L.
    Hills, Patrice
    Brown, Toni
    Lee, Moses
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 436 - 436
  • [10] New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3H)-benzothiazolones
    Atanasov, Gjorgji
    Rusew, Rusi I.
    Gelev, Vladimir M.
    Chanev, Christo D.
    Nikolova, Rosica
    Shivachev, Boris L.
    Petrov, Ognyan I.
    Apostolova, Margarita D.
    PHARMACEUTICALS, 2021, 14 (12)
12345