Immunogenic cell death in cancer and infectious disease

被引：0

作者：

Lorenzo Galluzzi

Aitziber Buqué

Oliver Kepp

Laurence Zitvogel

Guido Kroemer

机构：

[1] Weill Cornell Medical College,Department of Radiation Oncology

[2] Equipe 11 labellisée Ligue contre le Cancer,Department of Women's and Children's Health

[3] Centre de Recherche des Cordeliers,undefined

[4] INSERM,undefined

[5] U1138,undefined

[6] Université Paris Descartes/Paris V,undefined

[7] Sorbonne Paris Cité,undefined

[8] Université Pierre et Marie Curie/Paris VI,undefined

[9] Gustave Roussy Comprehensive Cancer Institute,undefined

[10] Metabolomics and Cell Biology Platforms,undefined

[11] Gustave Roussy Comprehensive Cancer Institute,undefined

[12] INSERM,undefined

[13] U1015,undefined

[14] Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428,undefined

[15] Université Paris Sud/Paris XI,undefined

[16] Karolinska Institute,undefined

[17] Karolinska University Hospital,undefined

[18] Pôle de Biologie,undefined

[19] Hopitâl Européen George Pompidou,undefined

[20] AP-HP,undefined

来源：

Nature Reviews Immunology | 2017年 / 17卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

The immunogenicity of cell death is determined by its antigenicity and its adjuvanticity.Cells infected by pathogens as well as cancer cells exhibit accrued antigenicity.Stress responses in dying cells cause the emission of adjuvant-like danger signals.Different sets of danger signals are associated with distinct variants of immunogenic cell death.Both pathogens and cancer cells interrupt danger signalling for their own benefit.Reinstating the immunogenicity of cell death holds promise for anticancer therapy.

引用

页码：97 / 111

页数：14

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