Tramadol and O-Desmethyl Tramadol Clearance Maturation and Disposition in Humans: A Pooled Pharmacokinetic Study

被引：0
|
作者：
Karel Allegaert
Nick Holford
Brian J. Anderson
Sam Holford
Frank Stuber
Alain Rochette
Iñaki F. Trocóniz
Horst Beier
Jan N. de Hoon
Rasmus S. Pedersen
Ulrike Stamer
机构：
[1] University Hospitals Leuven,Neonatal Intensive Care Unit and Center for Clinical Pharmacology
[2] University of Auckland,Department of Pharmacology and Clinical Pharmacology
[3] University of Auckland,Department of Anaesthesiology
[4] University of Bern,Department of Anaesthesiology and Pain Medicine
[5] University of Bern,Department of Clinical Research
[6] Hôpital Lapeyronie,Department of Anaesthesia and Intensive Care A
[7] University of Navarra,Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy
[8] Grünenthal GmbH,Institute of Public Health, Research Unit of Clinical Pharmacology
[9] University of Southern Denmark,undefined
来源：
Clinical Pharmacokinetics | 2015年 / 54卷
关键词：
Tramadol; Relative Standard Error; CYP2D6 Genotype; CYP2D6 Activity; Slow Metabolizers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：167 / 178
页数：11
相关论文
共 50 条
  • [1] Tramadol and O-Desmethyl Tramadol Clearance Maturation and Disposition in Humans: A Pooled Pharmacokinetic Study
    Allegaert, Karel
    Holford, Nick
    Anderson, Brian J.
    Holford, Sam
    Stuber, Frank
    Rochette, Alain
    Troconiz, Inaki F.
    Beier, Horst
    de Hoon, Jan N.
    Pedersen, Rasmus S.
    Stamer, Ulrike
    CLINICAL PHARMACOKINETICS, 2015, 54 (02) : 167 - 178
  • [2] Tramadol and O-demethyltramadol disposition in humans: a pooled study
    K Allegaert
    U Stamer
    B Anderson
    S Holford
    A Rochette
    I Troconiz
    R Pedersen
    N Holford
    Critical Care, 15 (Suppl 1):
  • [3] Optimized HPLC method for tramadol and O-desmethyl tramadol determination in human plasma
    Curticapean, Augustin
    Muntean, Daniela
    Curticapean, Manuela
    Dogaru, Maria
    Vari, Camil
    JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 2008, 70 (06): : 1304 - 1312
  • [4] Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk
    Salman, Sam
    Sy, Sherwin K. B.
    Ilett, Kenneth F.
    Page-Sharp, Madhu
    Paech, Michael J.
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 67 (09) : 899 - 908
  • [5] Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk
    Sam Salman
    Sherwin K. B. Sy
    Kenneth F. Ilett
    Madhu Page-Sharp
    Michael J. Paech
    European Journal of Clinical Pharmacology, 2011, 67 : 899 - 908
  • [6] The Tramadol Metabolite O-Desmethyl Tramadol Inhibits Substance P- Receptor Functions Expressed in Xenopus Oocytes
    Minami, Kouichiro
    Yokoyama, Toru
    Ogata, Junichi
    Uezono, Yasuhito
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 (03) : 421 - 424
  • [7] Differential tramadol and O-desmethyl metabolite levels in brain vs. plasma of mice and rats administered tramadol hydrochloride orally
    Tao, Q
    Stone, DJ
    Borenstein, MR
    Codd, EE
    Coogan, TP
    Desai-Krieger, D
    Liao, S
    Raffa, RB
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2002, 27 (02) : 99 - 106
  • [8] The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes
    Horishita, Takafumi
    Minami, Kouichiro
    Uezono, Yasuhito
    Shiraishi, Munehiro
    Ogata, Junichi
    Okamoto, Takashi
    Shigematsu, Akio
    PHARMACOLOGY, 2006, 77 (02) : 93 - 99
  • [9] Pharmacokinetics of tramadol, and its metabolite O-desmethyl-tramadol, in cats
    Pypendop, B. H.
    Ilkiw, J. E.
    JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2008, 31 (01) : 52 - 59
  • [10] Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk
    Ilett, Kenneth F.
    Paech, Michael J.
    Page-Sharp, Madhu
    Sy, Sherwin K.
    Kristensen, Judith H.
    Goy, Raymond
    Chua, Sebastian
    Christmas, Tracey
    Scott, Karen L.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 65 (05) : 661 - 666
12345