Regulation of promoter activity through electrostatic interactions with RNA polymerase

被引：1

作者：

Kamzolova S.G. ^{[1
]}

Osipov A.A. ^{[1
]}

Beskaravainyi P.M. ^{[1
]}

Dzhelyadin T.R. ^{[1
]}

Sorokin A.A. ^{[1
]}

机构：

[1] Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region

来源：

Biophysics | 2007年 / 52卷 / 2期

基金：

俄罗斯基础研究基金会;

关键词：

Electrostatic profile; Polymerase-promoter recognition; Promoter; RNA polymerase (Eσ[!sup]70[!/sup]);

D O I：

10.1134/S0006350907020054

中图分类号：

学科分类号：

摘要：

Electrostatic potential profiles were calculated for σ70- specific phage T4 promoters and four consensus-like synthetic promoters. Promoters could be classified according to the presence of specific elements of the electrostatic profile in the farther upstream region (-60 to -100). A correlation was found between the kind of such specific element and the functional behavior of the promoter. A general scheme is proposed whereby the promoter activity is regulated through electrostatic interactions between the upstream region of promoter DNA and the RNA polymerase α-subunit. © Nauka/Interperiodica 2007.

引用

页码：172 / 178

页数：6

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