Palladium-catalyzed amino group arylation of 1,3-disubstituted 1H-pyrazol-5-amine based on Buchwald–Hartwig reaction

被引：0
|
作者：
Mateusz Kucharek
Andrzej Danel
机构：
[1] University of Agriculture in Krakow,Department of Biotechnology and General Technology of Food, Faculty of Food Technology
[2] Cracow University of Technology,Faculty of Materials Engineering and Physics
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
5-; -arylaminopyrazoles; palladium catalyst; arylation; cross coupling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An efficient Pd-catalyzed C–N bond formation for the synthesis of different pyrazole derivatives using XPhos as a ligand and KOH as a base is presented. The developed procedure can be successfully applied for the synthesis of 5-N-aryl-1,3-disubstituted 1H-pyrazol-5-amines. Contrary to previously described procedures, this one proceeds in one step utilizing commercially available aminopyrazoles and aryl halides. Thus, a series of 5-N-aryl-1,3-disubstituted 1H-pyrazol-5-amines were obtained with satisfactory yields under optimized reaction conditions.
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页码：633 / 639
页数：6
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