A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

被引：0

作者：

Yongqiang Feng

Joris van der Veeken

Mikhail Shugay

Ekaterina V. Putintseva

Hatice U. Osmanbeyoglu

Stanislav Dikiy

Beatrice E. Hoyos

Bruno Moltedo

Saskia Hemmers

Piper Treuting

Christina S. Leslie

Dmitriy M. Chudakov

Alexander Y. Rudensky

机构：

[1] Howard Hughes Medical Institute and Immunology Program,Department of Comparative Medicine

[2] Ludwig Center at Memorial Sloan Kettering Cancer Center,undefined

[3] Memorial Sloan Kettering Cancer Center,undefined

[4] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS,undefined

[5] Pirogov Russian National Research Medical University,undefined

[6] Ostrovityanova 1,undefined

[7] Central European Institute of Technology,undefined

[8] Masaryk University,undefined

[9] Computational Biology Program,undefined

[10] Memorial Sloan Kettering Cancer Center,undefined

[11] School of Medicine,undefined

[12] University of Washington,undefined

来源：

Nature | 2015年 / 528卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Regulatory T cells need to express a diverse T-cell-receptor repertoire to control pathogenic self-reactive T cells; here it is shown that repertoire diversification depends on the intronic Foxp3 enhancer CNS3 acting at the regulatory T-cell-precursor stage to induce T-cell-receptor responsiveness to low-strength signals.

引用

页码：132 / 136

页数：4

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