Chemical structure and biological activity of steroidal saponins from Furcraea gigantea

被引：6
|
作者：
Pereira Da Silva B. [1 ]
Oliveira Campos P. [1 ]
Paz Parente J. [1 ]
机构：
[1] Laboratorio de Quimica de Plantas Medicinais, Nucleo de Pesquisas de Produtos Naturais, Universidade Federal Do Rio de Janeiro, CEP 21944-970, Rio de Janeiro
来源：
Chemistry of Natural Compounds | 2006年 / 42卷 / 3期
关键词：
Biological activity; Furcraea gigantea; Steroidal saponins; Structural elucidation;
D O I：
10.1007/s10600-006-0109-3
中图分类号：
学科分类号：
摘要：
A new bisdesmosidic furostanol saponin, along with a known spirostanol saponin, furcreastatin, were isolated from Furcraea gigantea Vent. (Agavaceae). The structure of the new saponin was elucidated as 3-[(O-6-deoxy-α-L- mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1å 3)-O-[O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2) -O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy]-(3β, 5α, 25R)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurost-12-one. The structural identification was performed using a combination of spectroscopic techniques and chemical conversions. Furcreastatin showed a powerful haemolytic effect in the in vitro assay, but the new bisdesmosidic furostanol saponin demonstrated only a significant inhibition of the capillary permeability activity. ©2006 Springer Science+Business Media, Inc.
引用
收藏
页码：316 / 321
页数：5
相关论文
共 50 条
  • [1] Chemical structure and biological activity of steroidal saponins from Furcraea gigantea
    da Silva, Bernadete Pereira
    Campos, Patricia Oliveira
    Parente, Jose Paz
    CHEMISTRY OF NATURAL COMPOUNDS, 2006, 42 (03) : 316 - 321
  • [2] Steroidal Saponins from Furcraea hexapetala Leaves and Their Phytotoxic Activity
    Calle, Juan M.
    Perez, Andy J.
    Simonet, Ana M.
    Guerra, Jose O.
    Macias, Francisco A.
    JOURNAL OF NATURAL PRODUCTS, 2016, 79 (11): : 2903 - 2911
  • [3] A new bioactive steroidal saponin from leaves of Furcraea gigantea
    da Silva, Bernadete P.
    Parente, Jose P.
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2006, 61 (09): : 1153 - 1157
  • [4] A new bioactive steroidal saponin from leaves of Furcraea gigantea
    Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21944-970 Rio de Janeiro, Brazil
    Z. Naturforsch. Sect. B J. Chem. Sci., 2006, 9 (1153-1157):
  • [5] Flavonol Glycosides and Cytotoxic Steroidal Saponins from Furcraea tuberosa (Agavaceae)
    Tapondjou, Leon A.
    Jenett-Siems, Kristina
    Siems, Karsten
    Weng, Alexander
    Melzig, Matthias F.
    NATURAL PRODUCT COMMUNICATIONS, 2017, 12 (03) : 347 - 350
  • [6] STEROIDAL SAPONINS OF MOLDOVAN PLANTS - STRUCTURE AND BIOLOGICAL-ACTIVITY
    KINTIA, PK
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 236 - AGFD
  • [7] Steroidal Glycosides from Furcraea foetida and Their Cytotoxic Activity
    Yokosuka, Akihito
    Sano, Tomoe
    Hashimoto, Ken
    Sakagami, Hiroshi
    Mimaki, Yoshihiro
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (10) : 1161 - 1166
  • [8] Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity
    Wang, Jing
    Song, Hua
    Wu, Xiaoxue
    Zhang, Shuyi
    Gao, Xuemin
    Li, Funan
    Zhu, Xuan
    Chen, Qing
    MOLECULES, 2018, 23 (03):
  • [9] Chemical and biological activity of triterpene Saponins from Medicago species
    Tava, Aldo
    Avato, Pinarosa
    NATURAL PRODUCT COMMUNICATIONS, 2006, 1 (12) : 1159 - 1180
  • [10] Steroidal Saponins from the Genus Smilax and Their Biological Activities
    Tian L.-W.
    Zhang Z.
    Long H.-L.
    Zhang Y.-J.
    Natural Products and Bioprospecting, 2017, 7 (4) : 283 - 298
12345