Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes

被引：26

作者：

Vieira, Ana ^{[1
,2
,3
]}

Wan, Yu ^{[1
,3
,4
,5
]}

Ryan, Yan ^{[6
]}

Li, Ho Kwong ^{[1
,2
]}

Guy, Rebecca L. ^{[4
,5
]}

Papangeli, Maria ^{[1
,2
]}

Huse, Kristin K. ^{[1
,2
]}

Reeves, Lucy C. ^{[1
,2
]}

Soo, Valerie W. C. ^{[1
,2
]}

Daniel, Roger ^{[6
]}

Harley, Alessandra ^{[6
]}

Broughton, Karen ^{[6
]}

Dhami, Chenchal ^{[6
]}

Ganner, Mark ^{[6
]}

Ganner, Marjorie A. ^{[6
]}

Mumin, Zaynab ^{[6
]}

Razaei, Maryam ^{[6
]}

Rundberg, Emma ^{[6
]}

Mammadov, Rufat ^{[6
]}

Mills, Ewurabena A. ^{[1
,2
]}

Sgro, Vincenzo ^{[1
]}

Mok, Kai Yi ^{[1
]}

Didelot, Xavier ^{[7
,8
]}

Croucher, Nicholas J. ^{[9
,10
]}

Jauneikaite, Elita ^{[3
,9
,10
]}

Lamagni, Theresa ^{[3
,4
,5
]}

Brown, Colin S. ^{[3
,4
,5
]}

Coelho, Juliana ^{[3
,4
,5
,6
]}

Sriskandan, Shiranee ^{[1
,2
,3
]}

机构：

[1] Imperial Coll London, Dept Infect Dis, London, England

[2] Imperial Coll London, Ctr Bacterial Resistance Biol, London, England

[3] Imperial Coll London, NIHR Hlth Protect Res Unit Healthcare Associated I, London, England

[4] UK Hlth Secur Agcy, Healthcare Associated Infect Fungal, AMR, AMU, London, England

[5] UK Hlth Secur Agcy, Sepsis Div, London, England

[6] UK Hlth Secur Agcy, Reference Serv Div, London, England

[7] Univ Warwick, Sch Life Sci, Coventry, England

[8] Univ Warwick, Dept Stat, Coventry, England

[9] Imperial Coll London, Sch Publ Hlth, London, England

[10] Imperial Coll London, MRC Ctr Global Infect Dis Anal, London, England

来源：

NATURE COMMUNICATIONS | 2024年 / 15卷 / 01期

基金：

英国医学研究理事会;

关键词：

SCARLET FEVER; INFECTIONS; ENGLAND;

D O I：

10.1038/s41467-024-47929-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1(UK) to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1(global) strains, invasive M1(UK) strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes covRS. The emergence of M1(UK) is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1(UK) clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1(UK) isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1(UK) point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.

引用

页数：11

共 22 条

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Brouwer, Stephan
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JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2025, 42 : 175 - 176
[3] Identification of Streptococcus pyogenes M1UK clone in Canada
Demczuk, Walter
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LANCET INFECTIOUS DISEASES, 2019, 19 (12): : 1284 - 1285
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Ruemke, Lidewij W.
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LANCET INFECTIOUS DISEASES, 2020, 20 (05): : 539 - 540
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Zhi, Xiangyun
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Sriskandan, Shiranee
MICROBIAL GENOMICS, 2023, 9 (04):
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Nature Communications, 14
[8] Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA
Davies, Mark R. R.
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NATURE COMMUNICATIONS, 2023, 14 (01)
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Vrenna, Gianluca
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PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2024, 43 (11) : e421 - e424
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Koizumi, Keiichi
Saito, Tomohiro
Takada, Ken
Fukao, Toshimichi
Numano, Fuminori
Oyachi, Noboru
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PEDIATRICS INTERNATIONAL, 2025, 67 (01)

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