Newborn pig skin as model membrane in in vitro drug permeation studies: A technical note

被引：0
|
作者：
Francesco Cilurzo
Paola Minghetti
Chiara Sinico
机构：
[1] P. Pratesi,Istituto di Chimica Farmaceutica e Tossicologica
[2] Università degli Studi di Milano,Dipartimento Farmaco
[3] Università degli Studi di Cagliari,Chimico
来源：
AAPS PharmSciTech | / 8卷 / 4期
关键词：
In vitro skin permeation experiment; human epidermis; newborn pig skin; benzoxazinones;
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摘要：
The suitability of newborn pig skin as an alternative to human epidermis in in vitro permeation studies was investigated. A set of 7 benzoxazinones was used to perform in vitro experiments by using a modified Franz diffusion cell and excised newborn pig skin as a membrane. The maximum flux through newborn pig skin (Jmax,p) was compared with the maximum flux through excised human epidermis (Jmax,h), available from the literature, by means of the factor of difference value FoD=Jmax,p/Jmax,h. The FoD values ranged from 0.48 to 1.91, indicating thatJmax,p andJmax,h were in the same order of magnitude.
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