Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level

被引：0

作者：

Evelien M Bunnik

Zelda Euler

Matthijs R A Welkers

Brigitte D M Boeser-Nunnink

Marlous L Grijsen

Jan M Prins

Hanneke Schuitemaker

机构：

[1] Sanquin Research,Department of Experimental Immunology

[2] Landsteiner Laboratory,Department of Infectious Diseases

[3] Center for Infection and Immunity Amsterdam,undefined

[4] Academic Medical Center,undefined

[5] University of Amsterdam,undefined

[6] Tropical Medicine and AIDS,undefined

[7] Center for Infection and Immunity Amsterdam,undefined

[8] Academic Medical Center,undefined

[9] University of Amsterdam,undefined

[10] Present addresses: Department of Medical Microbiology,undefined

[11] Center for Infection and Immunity Amsterdam,undefined

[12] Academic Medical Center,undefined

[13] University of Amsterdam,undefined

[14] Amsterdam,undefined

[15] The Netherlands (M.R.A.W.) and Crucell Holland BV,undefined

[16] Leiden,undefined

[17] The Netherlands (H.S.).,undefined

来源：

Nature Medicine | 2010年 / 16卷

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摘要：

The rapid mutation rate of HIV-1 enables its escape from neutralizing antibodies (NAbs) in infected individuals. Bunnik et al. now show that the immune pressure exerted by NAbs has, over the course of the HIV epidemic, altered the HIV-1 envelope glycoprotein such that HIV-1 variants isolated from recently infected individuals are more resistant to NAbs, compared with viral variants isolated from individuals infected at the start of the epidemic. Their results suggest the need to carefully select the envelope gene used in today's vaccine efforts.

引用

页码：995 / 997

页数：2

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