Antioxidant Properties of Glial Cell-Derived Neurotrophic Factor (GDNF)

被引：0
|
作者：
T. A. Mishchenko
E. V. Mitroshina
T. V. Shishkina
M. B. Vedunova
机构：
[1] N. I. Lobachevsky Nizhny Novgorod National Research State University,
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 166卷
关键词：
glial cell-derived neurotrophic factor; chronic oxidative stress; primary dissociated cultures; neuroprotection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We propose an in vitro model of chronic oxidative stress based on the use of glucose oxidase. Oxidative stress modeling leads to a significant increase in the number of dead cells in culture. It was shown that the glial cell-derived neurotrophic factor exhibits a pronounced anti-oxidant effect. Preventive application of 1 ng/ml glial cell-derived neurotrophic factor significantly reduced the percentage of dead cells in culture.
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页码：293 / 296
页数：3
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