There is a growing body of research devoted to the examination of character strengths as conceptualized by Values-In-Action (VIA) strengths classification system. However, there remains a dearth of research examining generic strengths use and its relationship with well-being, health-related quality of life (HRQOL), and VIA character strengths. In this crosssectional study, 135 undergraduate university students completed measures of strengths use, subjective well-being (SWB), self-esteem, self-efficacy, and HRQOL, and endorsed five top VIA strengths. Results revealed strengths use is a unique predictor of SWB, but not HRQOL. The VIA strengths of hope and zest were significant positive predictors of life satisfaction. The most commonly-endorsed VIA strengths were: love, humor, kindness, social intelligence, and open-mindedness. The least-endorsed VIA strengths were: leadership, perseverance, wisdom, spirituality, and self-control. Overall, results suggest an important link between generic strengths use and specific VIA strengths and their impact on SWB.