Immunogenicity of a novel, bivalent, plant-based oral vaccine against hepatitis B and human immunodeficiency viruses

被引：0
|
作者：
Sergei N. Shchelkunov
Rurik K. Salyaev
Sergei G. Pozdnyakov
Natalia I. Rekoslavskaya
Andrei E. Nesterov
Tatiana S. Ryzhova
Valentina M. Sumtsova
Natalia V. Pakova
Uliana O. Mishutina
Tatiana V. Kopytina
Rosemarie W. Hammond
机构：
[1] State Research Center of Virology and Biotechnology “Vector”,Molecular Plant Pathology Laboratory
[2] Institute of Chemical Biology and Fundamental Medicine,undefined
[3] Siberian Branch of the Russian Academy of Sciences,undefined
[4] Siberian Institute of Plant Physiology and Biochemistry,undefined
[5] Siberian Branch of the Russian Academy of Sciences,undefined
[6] United States Department of Agriculture,undefined
[7] Agricultural Research Service,undefined
来源：
Biotechnology Letters | 2006年 / 28卷
关键词：
Hepatitis B virus; Human immunodeficiency virus; Oral plant-based vaccine; Transgenic tomato;
D O I：
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中图分类号：
学科分类号：
摘要：
A synthetic chimeric gene, TBI-HBS, encoding the immunogenic ENV and GAG epitopes of human immunodeficiency virus (HIV-1) and the surface protein antigen (HBsAg) of hepatitis B virus (HBV), was expressed in tomato plants. Tomato fruits containing the TBI-HBS antigen were fed to experimental mice and, on days 14 and 28 post-feeding, high levels of HIV- and HBV-specific antibodies were present in the serum and feces of the test animals. Intraperitoneal injection of a DNA vaccine directing synthesis of the same TBI-HBsAg antigen boosted the antibody response to HIV in the blood serum; however, it had no effect on the high level of antibodies produced to HBV.
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页码：959 / 967
页数：8
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