An efficient and facile multicomponent synthesis of 4,6-diarylpyridine derivatives under solvent-free conditions

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作者
Hassan A. El-Sayed
Nabil H. Ouf
Ahmed H. Moustafa
机构
[1] Zagazig University,Department of Chemistry, Faculty of Science
[2] Tabuk University,Department of Chemistry, Faculty of Science
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关键词
Multicomponent synthesis; Solvent-free conditions; Pyridine-3-carbonitrile;
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摘要
We present an efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles (5a–j) via a four-component system of aromatic aldehydes (1), acetophenones (2), ethyl cyanoacetate (3), and ammonium acetate (4). The short reaction time coupled with the simplicity of the reaction procedure and clean reaction make this method one of the most efficient methods for synthesis of this class of compounds.
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页码:407 / 412
页数:5
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