Quantitative assessment of the influence of X-ray repair cross-complementing group 3 rs861539 polymorphism and cutaneous melanoma susceptibility

Previous studies evaluating the association between X-ray repair cross-complementing group 3 (XRCC3) rs861539 polymorphism and cutaneous melanoma susceptibility reported conflicting findings. To draw a more precise association between XRCC3 rs861539 polymorphism and cutaneous melanoma susceptibility, we searched PubMed, EMBASE and Web of Science for case–control studies. A total of eight case–control studies including 3463 cases of melanoma and 4216 controls were included in the meta-analysis. Overall, no significant associations were found between XRCC3 rs861539 polymorphism and cutaneous melanoma susceptibility under all four genetic models (TT vs CC: OR 0.99, 95 % CI 0.86–1.14; TC vs CC: OR 0.92, 95 % CI 0.83–1.01; dominant model: OR 0.94, 95 % CI 0.85–1.03; recessive model: OR 1.05, 95 % CI 0.92–1.19). In the subgroup by source of control, no significant associations were found in hospital-based and population-based subgroup. This meta-analysis suggested that the XRCC3 rs861539 polymorphism was not a risk factor for cutaneous melanoma susceptibility.