Green hen weed (Petiveria alliacea) protects against bisphenol A-induced toxicity in the hepato-renal system

Bisphenol A (BPA) exposure has been shown to induce oxidative stress. Despite advances in medicine, treatment implementation remains a challenge; however, medicinal plants have shown usefulness in the management of oxidative stress-induced pathogenesis. The study explored the effect of ethanolic extracts of Petiveria alliacea (P. alliacea), commonly called green hen weed in BPA-induced alterations in the hepato-renal system of a rat model. BPA-intoxicated rats were given water, 50, 100, and 200 mg/kg ethanolic extracts of P. alliacea (EPA) separately for 21 days. BPA administration increased plasma alanine transferase, aspartate transferase, creatinine, and total bilirubin. Furthermore, it decreased the activity of catalase, glutathione-S-transferase, glutathione, and malondialdehyde concentrations in the kidney and liver. Administration of EPA at all doses restored all the values to near normalcy relative to the control in both the kidney and liver. Histology also confirmed these findings. Ethanolic leaf extracts of P. alliacea provide protection against BPA-induced toxicity in the hepato-renal system through the antioxidant pathways. © 2023, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.