Solving the centriole disengagement puzzle

被引：0
|
作者：
Andrew M. Fry
机构：
[1] Andrew M. Fry is at the University of Leicester,Department of Biochemistry
[2] Leicester LE1 9HN,undefined
[3] UK,undefined
来源：
Nature Cell Biology | 2015年 / 17卷
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摘要：
The microcephaly protein, Cep215, contributes to the engagement of duplicated centrioles in interphase. Now two distinct pools of Cep215 at centrosomes are identified, one bound to Cep68 and the other to pericentrin. Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.
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页码：3 / 5
页数：2
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