Measurement uncertainty (MU) arising at different stages of a measurement process can be estimated using analysis of variance (ANOVA) on replicated measurements. It is common practice to derive an expanded MU by multiplying the resulting standard deviation by a coverage factor k. This coverage factor then defines an interval around a measurement value within which the value of the measurand, or true value, is asserted to lie for a desired confidence level (e.g. 95 %). A value of k = 2 is often used to obtain approximate 95 % coverage, although k = 2 will be an underestimate when the standard deviation is estimated from a limited amount of data. An alternative is to use Student's t-distribution to provide a value for k, but this requires an exact or approximate degrees of freedom (df). This paper explores two different methods of deriving an appropriate k in the case when two variances from an ANOVA (classical or robust) need to be combined to estimate the measurement variance. Simulations show that both methods using the modified coverage factor generally produce a confidence interval much closer to the desired level (e.g. 95 %) when the data are approximately normally distributed. When these confidence intervals do deviate from 95 %, they are consistently conservative (i.e. reported coverage is higher than the nominal 95 %). When outlying values are included at the level of the larger variance component, in some cases the method used for robust ANOVA produces confidence intervals that are very conservative.
机构:
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USAUniv Calif Davis, Genome Ctr, Davis, CA 95616 USA
Fletcher, Kyle
Han, Rongkui
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA
Univ Calif Davis, Plant Biol Grad Grp, Davis, CA 95616 USAUniv Calif Davis, Genome Ctr, Davis, CA 95616 USA
Han, Rongkui
Smilde, Diederik
论文数: 0引用数: 0
h-index: 0
机构:
Naktuinbouw, Postbus 40,Sotaweg 22, NL-2370 AA Roelofarendsveen, NetherlandsUniv Calif Davis, Genome Ctr, Davis, CA 95616 USA
Smilde, Diederik
Michelmore, Richard
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA
Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA
Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA
Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USAUniv Calif Davis, Genome Ctr, Davis, CA 95616 USA