Using Liposomal and Intranasal Drugs and Pioglitazone for the Treatment and Prevention of Alzheimer’s Disease (Review)

被引：0
|
作者：
V. V. Veselov
N. N. Eroshchenko
V. M. Trukhan
A. V. Zvyagin
A. E. Nosyrev
机构：
[1] Sechenov First Moscow State Medical University (Sechenov University),
来源：
Pharmaceutical Chemistry Journal | 2023年 / 57卷
关键词：
Alzheimer’s disease; pioglitazone; liposomes; intranasal administration; blood(brain barrier;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review article provides information on the development of liposomal drug delivery systems to cross the blood(brain barrier (BBB). Information on the use of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, for the prevention and treatment of Alzheimer’s disease is provided. Methods for modifying the surface of liposomes to ensure transport through the BBB are considered in detail. Various forms for intranasal administration of drugs to improve their passage through the BBB are also highlighted. The presented information allows us to conclude that it is expedient to develop an intranasal liposomal form of pioglitazone for the treatment and prevention of Alzheimer’s disease.
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页码：1 / 9
页数：8
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