Basal Bolus Insulin Regimens from Diagnosis Improve Honeymoon Period Compared with Twice Daily Mixed Insulin Regimens

Background: In the UK at present, different centres use different insulin regimens for paediatric patients at diagnosis of Type 1 Diabetes. Some centres start all children on basal bolus or multiple dose injection (MDI) regimens, whereas others still use twice daily (BD) mixed insulins in certain age groups, partly because of difficulties in supporting insulin administration in school. Since 2008, all children newly diagnosed with diabetes attending Nottingham Children's Hospital have been started on a MDI regimen, regardless of age. We aimed to assess whether either of these insulin regimens produced better honeymoon HbA1Cs and duration of honeymoon period.