Combined Effect of Bone Morphogenetic Protein-2 and Erythropoietin on Regeneration of Cranial Bone Defects in Mice

被引：0

作者：

A. V. Gromov

M. S. Bartov

P. A. Orlova

V. N. Manskikh

M. S. Krivozubov

T. M. Grunina

M. S. Manukhina

N. V. Strukova

K. E. Nikitin

V. G. Lunin

A. S. Karyagina

A. L. Gintsburg

机构：

[1] Ministry of Health of the Russian Federation,N. F. Gamaleya National Research Center of Epidemiology and Microbiology

[2] M. V. Lomonosov Moscow State University,A. N. Belozersky Research Institute of Physico

[3] All-Russian Research Institute of Agricultural Biotechnology,Chemical Biology

来源：

Bulletin of Experimental Biology and Medicine | 2019年 / 167卷

关键词：

BMP-2; erythropoietin; Epostim; regeneration of bone tissue; critical size defect;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Using mouse model of regeneration of critical size cranial defects, we studied combined effect of 1 and 10 μg of BMP-2 of prokaryotic origin and recombinant erythropoietin (Epostim) injected subcutaneously in the area of bone defect in a total dose of 6000 U/kg. Erythropoietin considerably improved quantitative and qualitative characteristics of the bone tissue in the site of implantation when used in combination with BMP-2 in both concentrations.

引用

页码：408 / 412

页数：4

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